Category Archives: Uncategorized

GammaCore: Device for Headache Treatment


The vagus nerve stimulation device was first approved by the FDA in April 2017 for the acute treatment of episodic cluster headaches.  January 2018, announcement of the new Migraine treatment marks gammaCore’s first approval for Migraine.

  •         gammaCore® (nVNS) is a non-invasive, hand-held medical device that treats the acute pain of a cluster headache attack or a Migraine attack by stimulating the vagus nerve.
  •         The device is held to the neck and mild electrical currents pass through the skin to stimulate the fibers of the vagus nerve, a large nerve system that connects the gut to the brain . gammaCore passed the test in clinical studies as a new Migraine treatment, showing a significant reduction in acute Migraine or cluster headache pain after use of the device.

·         gammaCore is the third neuromodulation device approved by the FDA for acute Migraine treatment. Cefaly ACUTE was approved for acute use in September 2017.  Meanwhile, eNeura’s TMS unit was approved for acute use in December 2013. While each device operates differently, they all offer patients the option of aborting a migraine attack without drugs, and minimal side effects.

Call The Manhattan Center For Headache & Neurology to find out more about this device! We look forward to seeing you!

By: Rajni Bala, NP

Primary Headache Associated with Sexual Activity

This headache disorder is rare. It is previously known as pre-orgasmic (appears during sex and increases during mounting excitement) or orgasmic headache (sudden explosive headache followed by severe throbbing immediately before at the point of orgasm). It is considered a primary headache because there is no other underlying cause.

This headache is usually bilateral and often located to occipital areas. Severe headache due to sexual activity can lasts anywhere from 1 minute to 24 hours. Milder headache can last up to 3 days. This headache may have migrainous features and should be differentiated from a migraine triggered by sexual activity. Can occur in anyone who is sexually activity regardless of age. More common among men than women.

People with new onset headache associated with sexual activity or if never evaluated for this headache should consider seeing a doctor to r/o underlying causes. Imaging studies may be ordered to rule out serious conditions such as subarachnoid hemorrhage, arterial dissection and reversible cerebral vasoconstriction syndrome.

Medications are available for headache associated with sexual activity, and should usually be prescribed after all imaging studies are completed.

American Migraine Foundation (2019)

Tanesha Reynolds, DNP, FNP-BC, Certified in Headache Medicine


Cluster Headaches

The term cluster headache comes from the recurrence of headache attacks usually in a series (cluster periods) lasting for weeks or months, separated by remission periods (periods of headache freedom) usually lasting months or years.

Cluster headaches are often said to be the most painful of all headaches. They have been described as “boring,” “bearing,” “burning,” “like a hot poker in the eye,” and as “suicide headaches.” The age of onset of cluster headache is most often between 20 and 40, and they are more common in men than women at a ratio of 3:1.

Cluster headache is a primary headache disorder that consists of severe headaches on one side of the head associated with :

  • red or teary eyes,
  • runny or stuffy nose,
  • flushing or sweating of the face or a sense of restlessness and agitation.

Cluster headache is classified as a trigeminal autonomic cephalalgia or TAC:

Trigeminal refers to cranial nerve 5, which is the nerve that controls sensation of the face. For this reason, the pain associated with cluster headache often localizes to the face particularly around and behind the eye.

Autonomic refers to symptoms like red or teary eye, runny or stuffy nose, sweating or flushing of the face, drooping of the eyelid, or sense of fullness in the ear. In cluster headache, these symptoms occur on the same side as the pain.

Symptoms of Cluster Headache

Cluster headaches are attacks of severe pain lasting 15-180 minutes and occurring from once every other day up to eight times in one day—averaging 2 per day over typically 4-6 weeks then entirely disappearing for 6-12 months.

  • Severe Pain
  • Unilateral (on one side of the head)
  • Orbital (near the orbit, the bone framing the eye), supraorbital (above the orbit), temporal (at the temple) or a combination of those sites and sometimes more towards the back of the head

These attacks also include one or more cranial autonomic symptoms on the same side as the pain (ipsilaterally):

  • Red eye (conjunctival injection)
  • Eyelid swelling (edema)
  • Forehead and facial sweating
  • Tearing (lacrimation)

Abnormal small size of the pupil (miosis)

Nasal congestion

Runny nose (rhinorrhea)

Drooping eyelid (ptosis)


There are no diagnostic tests to confirm cluster headache. Diagnosis is accomplished by reviewing personal and family medical history, considering associated symptoms, and an examination. .

Acute treatment

The most commonly used therapies to shorten or abort a cluster attack are:

  • High-flow 100% oxygen (O2) by mask
  • Sumatriptan nasal spray or in the skin (subcutaneous) injection
  • DHE-45 nasal spray or injection
  • Zolmitriptan nasal spray


By: Rajni Bala, NP

High Altitude Headache (HAH)

A headache is the most common symptom that one experiences usually over 3000 meters above sea level. Other common complaints are loss of appetite, nausea and sleep disturbances.

A high altitude headache must have at least 2 of the following characteristics:

  1. Pain on both sides of the head
  2. Located to the frontal or frontotemporal area
  3. Dull or pressure-like quality
  4. Mild or moderate intensity
  5. Aggravated by exertion, movement, straining, coughing, or bending

The headache must develop within 24 hours after ascent and resolves within eight hours of descent.


A HAH can be prevented by a slower ascent, usually 300 meters per day, allowing 2 days to become acclimated before engaging in strenuous exercise at high altitudes, avoiding alcohol, and increasing hydration.


Over the counter medications such as paracetamol or ibuprofen have proven to be effective in treating HAH. Triptans are also effective.

Acetazolamide may reduce susceptibility to acute high altitude sickness.

Tanesha Reynolds, DNP, FNP-BC, Certified in Headache Medicine

If you are experiencing a HAH that has not gone away, please schedule an appointment to see one of our providers at MCHN.

Cyclical Vomiting Syndrome (CVS) and Migraine

Cyclical vomiting syndrome is accepted as a migraine syndrome from childhood by the International Headache Society. The criteria for diagnosis according to The Migraine Trust (2019) is:


  • A. At least five attacks overall fulfilling criteria B and C;
  • B. Episodic attacks, stereotypical in the individual patient, of intense nausea and vomiting, lasting one hour to five days;
  • C. Vomiting during attacks occurs at least four times per hour for at least one hour;
  • D. Symptom-free between attacks;
  • E. Not attributed to another disorder.
  • History and physical examination do not show signs of gastrointestinal disease.

Migraine medications can sometimes help stop or even prevent cyclic vomiting episodes. These meds may be recommended for patients with frequent and long lasting symptoms and even patients with family history of migraines. Treatment usually focuses on controlling the signs and symptoms. Prescriptions may include: anti-nausea medications, pain-relieving medications, anti-reflux medications, antidepressants and anti-seizure medications. IV fluids are often necessary to prevent dehydration. Treatment is individualized based on severity, duration or presence of complications.

If you are experiencing CVS with no evidence of gastrointestinal disease, you may be having migraines, which require treatment by a headache specialist. At MCHN, we provide IV hydration and medications to treat CVS.

Tanesha Reynolds, DNP, FNP-BC, Certified in Headache Medicine

What are Trigger Point Injections?

Stress and tension can cause the muscles of your neck and back to become tight and form knots. The pain from this tightness can radiate to your scalp and head which may develop into a migraine. The migraine is the result of stress induced tension.  Trigger point injections may be able to relieve your stress induced migraines. Injections of lidocaine are administered into the trigger points of the back and neck. This helps address the pain sensation and give your muscles a chance to calm down by inactivating pain receptors. Discuss therapy with one of our caring providers. A specialized treatment plan will be developed just for you. Treatment may consist of a combination of therapies.

Post-Traumatic Headache (PTH)


Post-traumatic headache (PTH) is a headache that develops within 7 days after injury or after regaining consciousness.  The cause of PTH could be related to the release of certain chemicals, the swelling of important brain structure or even brain shrinkage. More severe injuries require a CT or MRI scan to rule out a brain bleed. Patients that have head injury may find it hard to perform daily activities, miss school, miss work and in general experience a lower quality of life. Treatment for PTH includes: medications (anti-inflammatories, pain medicines and triptans) used during the weeks of initial treatment. When the headaches persist, preventative medicine should be considered like: antidepressants, blood pressure pills, and anti-seizure medicines. Non drug therapies are also effective: physical therapy, biofeedback/relaxation therapy, nerve stimulators and cognitive behavioral therapies. Please contact The Manhattan Center for Headache and Neurology to learn more about PTH and treatments. We look forward to hearing from you!

Episodic to Chronic Headaches

Why are my headaches now daily?

There are several risk factors that put the headache patient at risk for exacerbation. Many of these risk factors are modifiable and some are not such as genetic predisposition.

Modifiable risk factors:

  • Medication overuse – primarily combination analgesics combined with caffeine (over-the-counter or prescription), Caffeine, Ergotamine, Opiates, Over-the counter or prescribed analgesics, and Triptans. All these medications can be effective in treating episodic headache when used on an occasional basis. However, when used more than two days a week, they may transform and aggravate headache.
  • Stress – Stress is the most common trigger for headache in headache sufferers. Frequent life changes and chronic daily stressors or “hassles” can lead to the development of chronic headaches. These stressors may also result in anxiety and depression.


  • Sleep disturbance – Chronic inadequate sleep of approximately 6 hours or less per night creates risk for more headaches. Most common sleep problem for headache patients is insomnia (trouble falling asleep, staying asleep, or poor quality sleep).



  • Obesity – Obesity increases headache frequency. A person with a BMI > 30 is considered obese or waist >35 inches in a woman and >40 inches in a man



  • Caffeine – Caffeine can aggravate headaches the same way medication overuse can. Frequent use of caffeine can also be a risk factor for headache progression. Caffeine is added to certain pain medications because it can be beneficial for migraine when used occasionally and in moderation, defined ideally as two days per week or less.


An understanding of the specific causes or contributing factors that lead to progression, and then reversing them, is key to successful treatment. Please call us for a consultation if your headaches have transformed from episodic to daily.

By: Tanesha Reynolds, DNP, FNP, BC in Headache Medicine